(a) Timeline of Klebsiella pneumoniae isolation and antimicrobial therapy. All antibiotics were administered intravenously, except for colistin, which was nebulized. Only antibiotics administered for at least 2 days are presented. Resp.: respiratory. Only Klebsiella pneumoniae isolates in bold were stored and available for retrospective analysis.
Le céfiderocol, une céphalosporine conjuguée à un sidérophore, est un médicament prometteur utilisé pour traiter les infections causées par des bactéries gram-négatives résistantes aux carbapénèmes. Cette étude rapporte un cas de pneumonie provoquée par plusieurs pathogènes gram-négatifs, ayant développé une résistance au céfiderocol en l’espace de 32 jours de traitement.
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English version 🇬🇧
(a) Timeline of Klebsiella pneumoniae isolation and antimicrobial therapy. All antibiotics were administered intravenously, except for colistin, which was nebulized. Only antibiotics administered for at least 2 days are presented. Resp.: respiratory. Only Klebsiella pneumoniae isolates in bold were stored and available for retrospective analysis.
Cefiderocol, a siderophore-conjugated cephalosporin, is a promising drug for treating infections caused by carbapenem-resistant gram-negative bacteria. This study reports a case of pneumonia caused by several gram-negative pathogens, which developed resistance to cefiderocol within 32 days of treatment.
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