Deciphering Surface Proteins, Pathogenicity and Host–Pathogen Dynamics of Mycoplasma agalactiae: Paving the Way for Vaccine Development

Mycoplasma agalactiae is a key pathogen responsible for contagious agalactia in small ruminants, a disease with significant economic and animal welfare impacts. The pathogen’s ability to evade host immune responses and establish persistent infections is largely attributed to its diverse repertoire of surface proteins and pathogenicity-associated determinants. These factors not only mediate host–pathogen interactions but also play pivotal roles in immune evasion, defense, and modulation at different stages of disease progression, making them prime targets for vaccine development.

This talk will provide an overview of our research into the molecular mechanisms underlying M. agalactiae pathogenesis, with particular focus on host cell interactions and the immune characteristics of novel antigenic membrane proteins, as well as the well-established Vpma surface lipoproteins. Insights into other key pathogenicity factors influencing the pathogen’s ability to invade host tissues and persist in the immunocompetent host will also be discussed. By advancing our understanding of M. agalactiae pathogenesis, these findings are expected to inform the development of effective vaccines to combat contagious agalactia in livestock.