Antimicrobial resistance (AMR) represents a major global public health threat. The emergence and spread of AMR among clinically relevant bacteria are driven by the exchange of resistance genes between bacteria originating from human, animal, and environmental sources. Several studies have shown that resistance genes can cross ecological boundaries between these compartments, spreading rapidly on a global scale. To effectively combat the emergence and dissemination of AMR, research, monitoring, and intervention strategies must adopt a One Health approach that integrates human, animal, and environmental health.

In this context, the UMR INSERM 1092 applies the One Health framework to explore the eco-evolutionary trajectories of AMR spread and to support the development of surveillance systems.

A major mechanism by which clinically relevant bacteria acquire new resistance traits is through the acquisition of resistance plasmids. These plasmids are mobile genetic elements capable of carrying multiple resistance genes. However, our understanding of the pathways by which these plasmids move across environmental, animal, and human ecosystems-and are ultimately acquired by potentially pathogenic human bacteria-remains limited.

The main objective of the research project, within which this Master’s 2 internship is embedded, is to identify the eco-evolutionary factors that promote the transmission of AMR within the One Health continuum.

Within this project, the internship objective focuses on identifying bacteria that facilitate the transfer of resistance plasmids between the environment, animals, and humans.